SO_2 impurities are commonly encountered in practical industrial exhaust gases. During catalytic purification processes, SO_2 molecules compete with reactants for active sites. Particularly, SO_2 can undergo chemical reactions with noble metals, forming sulfate salts. This interaction weakens electron transfer capabilities, leading to severe and irreversible sulfur poisoning of catalysts. Therefore, efficiently regenerating sulfur-poisoned catalysts or designing sulfur-resistant catalysts has become a crucial challenge in the field of environmental catalysis. This paper begins by analyzing the adsorption, migration, and transformation processes of SO_2 on noble-metal based catalysts. It then explores methods for regenerating sulfur-poisoned catalysts and elucidates the involved mechanisms. Subsequently, it summarizes strategies for designing noble-metal based catalysts with excellent sulfur-resistance, including active phase regulation, support modification, and the construction of encapsulated structures, emphasizing that the key to developing sulfur-resistant catalysts lies in enhancing metal-metal/support interactions. Finally, it discusses future research directions for noble-metal based catalysts with excellent sulfur-resistance, aiming to provide guidance for the optimized design of industrial sulfur-resistant catalysts.