Coupling NH_3-SCR denitration and VOCs purification in flue gas treatment of typical industries such as waste incineration and steel smelting, developing multi-pollutants synergistic control theory and technology to collaboratively remove NO_x and VOCs is of great importance. It possesses important scientific significance, ecological and economic benefits. At present, the synergistic catalytice limination of NO_x and VOCs has attracted wide attentions, and relevant studies mainly focus on the catalytic performance of synergistic catalysts. These current studies are still preliminary. Further research efforts are needed to develop more effective synergistic catalyst and investigate the interaction mechanism of SCR and VOCs oxidation. The construction and regulation of the acid/redox dual-core active site of the synergistic catalyst, the understanding of the mechanism of the acid/redox dual-cycle reaction pathway, and the improvement of anti-poisoning ability of the catalyst are three key issues needed to be considered in the following researches. The first step to solve these key scientific problems is still to design and prepare catalysts with high activity, stability and anti-poisoning ability. The next step is to investigate the chemical composition and structural properties of the catalyst and illustrate the microchemical environment of dual-core sites. Further, the efficient synergistic mechanism of the catalytic process and the anti-poisoning effect of catalyst are to be studied by in situ technology and theoretical calculation. This review summarizes the current research progress of NO_x and VOCs synergic catalytic purification technology, proposes the technical bottleneck, analyzes the key scientific issues, and puts forward corresponded strategic solutions, aiming to shed light on developing multi-pollutant removal in future.