Taking sulfamethazine (SM1), enrofloxacin (ENR), chlortetracycline (CTC) and trime-thoprim (TMP) as the research objects, the degradation processes of typical antibiotics in aquaculture water, as well as their distribution and degradation in water-sediment system were studied by control experiments. The results showed that in aquaculture water, the hydrolysis half-lives of SM1, ENR and CTC with the initial concentration of 50 μg·L-1 were 152.6, 115.9, and 59.2 d, respectively, while TMP hardly hydrolyzed. Under simulated sunlight with light intensity of 3 000 lux, the photolysis half-lives of SM1, ENR, and CTC were 17.4, 33.0, and 3.5 d respectively, while TMP hardly photodegraded. The biodegradation half-lives of SM1, ENR, CTC and TMP were 31.3, 328.5, 5.3, and 259.6 d, respectively. The comprehensive degradation rate of each antibiotic was faster than the degradation rate of any single reaction. In the water-sediment systems of 3 different aquaculture types (fish, shrimp, crab), all the four antibiotics in the aqueous phase decayed rapidly within 0~7 days. At equilibrium, the adsorption coefficients (Kd) of SM1, ENR, CTC and TMP were 1.52~3.12, 26.65~40.44, 4.79~12.05, and 1.16~3.85 L·kg-1, and there were obvious differences in the adsorption coefficients of antibiotics in different system. In sediments, the degradation half-lives of CTC and TMP were long (29.1~60.5 d and 26.7~42.5 d), while the half-life of SM1 was short (8.2 ~20.5 d). The half-life of ENR varied greatly in different sediments. The persistence of antibiotics in sediments was generally higher than that in water.