In order to study the migration characteristics of nuclide in groundwater, the influence of permeability coefficient of rock mass in fractured zone on nuclide migration was discussed by numerical simulation software Visual Modflow. The results show that non-penetrating fractured zones causes negative effects on the migration rate of nuclides. Nuclide concentration decreases quickly and then slowly during the migration and decay process. The influence of permeability coefficient of fractured zone on the change of nuclide concentration decreases gradually with time. When the permeability coefficient of the fractured area was 30 times of that of the surrounding rock, the maximum nuclide concentration in the groundwater decreases from 4.65×106 Bq/L to 1.22 Bq/L within 90 years. The functional relationship of the maximum nuclide concentration, the diffusion time and the relative permeability coefficient is fitted asc=0.269 16×e-n/6.544 59+0.575 19×e-n/0.985 8+0.118 95.