In the field of new energy vehicles and related sectors, treating butyl acetate (BA), a typical oxygen-containing volatile organic compound (VOC), is becoming increasingly important. The surface structure and physicochemical properties of a CeO_2-U catalyst were adjusted by introducing 0.5% Pd, and compared with Al_2O_3 and TiO_2 catalysts containing the same Pd loading. Characterizations using SEM, XPS, in-situ DRIFTS, and other methods were conducted to explore the synergistic effect of Pd and Ce active components on catalytic oxidation of BA. The results showed that the introduction of Pd increased CeO_2-U′s CO_2 yield from 77.8% to 90.7% at 220 ℃, significantly promoting the deep oxidation process of BA and alleviating the issue of CO_2 selectivity delay. The introduction of Pd enhanced the mobility and reactivity of lattice oxygen in CeO_2, increased the proportion of surface Ce^3+, and boosted surface oxygen vacancy concentration. Additionally, the catalytic oxidation mechanism of BA over Pd/CeO_2-U was confirmed through in-situ DRIFTS analysis, indicating that the L-H mechanism was followed at low temperatures (T<200 ℃), while the MvK reaction mechaism occured followed at high temperature (T>200 ℃). It was found that the decomposition of intermediate carboxylate served as the rate-controlling step. These findings have implications for controlling BA in the field of related sectors.