The rapid urbanization has led to the discharge and generation of large amounts of organic solid waste, such as sewage sludge (SS) and food waste (FW ). The introduction of a microbial electrolysis cell (MEC) into the anaerobic digestion (AD) process can realize efficient methane conversion. In this study, the effects of intermittent power-on and electrode inversion on the MEC-Continuous stirred tank reactor (CSTR) were investigated. The results showed that the MEC-CSTR operated well under an applied voltage of 1.2 V and SRT= 15 d, with a methane yield of (741.9+99.2) mL/L-reactor/d. A short power outage period (2d) did not adversely affect the performance of the system, whereas power outage of 7d decreased the organic hydrolysis effect and methane yield of the reactor. Furthermore, successive electrode switching induced a decrease in the methane yield (541.7+32.0) mL/L-reactor/d). However, neither the power outage nor the electrode inversion caused a significant effect on the physical and chemical properties of the digestate or the hydrolysis of organic matter. This study can provide a new solution for MEC system to enhance the optimal implementation of SS and FW scale disposal and anaerobic energization project.