The rapid urbanization has led to the discharge and generation of large amounts of organic solid waste, such as sewage sludge (SS) and food waste (FW). The introduction of a microbial electrolysis cell (MEC) into the anaerobic digestion (AD) process can realize efficient methane conversion. In this study, the effects of intermittent power-on and electrode inversion on the MEC-Continuous stirred tank reactor (CSTR) were investigated. The results showed that the MEC-CSTR operated well under an applied voltage of 1.2 V and sludge retention time (SRT) of 15 d, with a methane yield of (741.9±99.2) mL/L- reactor/d. A short power outage period (2 d) did not adversely affect the performance of the system, whereas power outage of 7 d decreased the organic hydrolysis effect and methane yield of the reactor. Furthermore, successive electrode switching induced a decrease in the methane yield ((541.7 ± 32.0) mL/L-reactor/d). However, neither the power outage nor the electrode inversion caused a significant effect on the physical and chemical properties of the digestate or the hydrolysis of organic matter. This study can provide a new solution for MEC system to enhance the optimal implementation of SS and FW scale disposal and anaerobic energization project.