VOCs and NO_x are precursors of PM_2.5 and ozone, which can pose a severe threat to both the environment and human health. Catalytic technology is considered a promising multi-pollution treatment for the synergistic elimination of VOCs and NO_x, and is expected to achieve reductions in PM_2.5 and ozone levels. In recent years, researchers have conducted extensive studies on catalysts forthe synergistic removal of VOCs and NO_x, and the reaction mechanism of synergistic catalysis has alsobeen studied in-depth. This paper reviews the current research progress on catalysts for the synergistic catalysis of VOCs and NO_x. It discusses the latest research on different types of catalysts for the synergistic removal of VOCs and NO_x, including vanadium-based catalysts, manganese-based catalysts, and molecular sieve catalysts. The influence of the structure and physicochemical properties of catalysts on the activity and reaction pathways have been deeply discussed. Additionally, the reaction mechanism of the synergistic catalytic process and the impact of each component on the catalytic reaction are explored. The article also analyses the possible problems and deficiencies of VOCs and NO synergistic catalysis in practical applications. Finally, the article provides suggestions for the future development of multi-pollution synergistic catalysts.