Covalent organic frameworks material COF-PD/AgI modified by AgI was prepared with 2,5-diaminopyridine and 1,3,5-triformylresorcinol as precursors. The morphology and composition of the material were characterized by scanning electron microscopy (SEM), X - ray powder diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). Methylene blue (MB) and rhodamine B (RhB) were used as simulated organic pollutants to determine the photocatalytic degradation performance of the material under visible light. E. coli was used as the model strain to determine the antimicrobial properties. The results showed that when the dosage of COF-PD/AgI nanocomposite was 0.036 g, it had good photocatalytic degradation performance for methylene blue and rhodamine B. When the concentration of COF-PD/AgI material was 150 mg/L, the effect of bacteriostatic ring was the best. When the minimum concentration of COF-PD/AgI was 4 mg/L, the growth of E. coli was completely inhibited.